بررسی میزان موفقیت متیل پردنیزولون استات در دفع سنگ حالب دیستال

Background and Purpose: Acute renal colic is a common complaint from patients entering the emergency departments. Although, urethral lithotripsy and extracorporeal shock wave lithotripsy are known to be effective, the role of medical-expulsive therapy for the treatment of this disease has not yet been established. This study assessed the clinical efficacy of addition methylprednisolon acetate in the medical-expulsive therapy of distal ureterolithiasis. Materials and Methods: Eighty five (85) consecutive patients with a symptomatic distal urethral stone were included in our study and randomized to one of two home treatment groups. Group A patients (n = 45) received tramadol (50mg bid) and hydrochlorothiazide (50 mg daily) for 21 days, and group B patients (n = 40) were treated with a corticosteroid drug (methylprednisolon acetate 40mg intra-muscular on 0, 7 and 14 days after treatment), in addition to tramadol and hydrochlorothiazide. The treatment duration was 21 days. All patients were re-evaluated after 21days with a clinical examination and KUB. Results: The mean stone size was 5.2mm and 5.8mm in groups A and B respectively (P value>0.05). Both groups had a significant difference in expulsion rate (20(44.4%) for group A and 32 (88%) for group B (P value<0.001). Conclusion: Our results suggest that the use of a corticosteroid drug in association with tramadol and hydro-cholorothiazid appeared to induce an increase in the expulsion rate.